Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Debunking de novo NAD+ Synthesis in C. elegans: Artifacts Arising from Impure Quinolinic Acid
Axenic culture system reveals that C. elegans lacks the necessary mechanisms for de novo synthesis of NAD+. Commercially available quniolinic acid products contain nicotinic acid impurity, potentially producing misleading information.
Laromestrocel: Stem Cells for Alzheimer's Disease?
Treatment of Alzheimer’s disease has seen recent advancement with anti-amyloid therapies, but these are only partially effective and come with risks. Stem cell treatments offer new promise, and new clinical trial results point to both safety and potential efficacy.
Structure of human mGlu3-arrestin complex
In this paper, we reported the structures of two mGlu3-βarr1 complex with 2:1 and 2:2 stoichiometries. The mGlu3 in an inactive conformation engages βarr1 through phosphorylated C-terminal tail and intracellular loops.
