Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Revolutionizing Liver Recovery: My Journey with hAAMs in Regenerative Medicine
As a researcher in regenerative medicine, I’m fascinated by the body’s ability to heal itself. My recent study in npj Regenerative Medicine explores human alternatively activated macrophages (hAAMs) to promote liver regeneration, offering a promising step toward innovative cell therapies.
Structure of human mitochondrial Mg2+ channel Mrs2
Mrs2 is a mitochondrial Mg2+ channel that is essential for metabolic function. We determined cryo-EM structures of human Mrs2 under different conditions, revealing a novel molecular mechanism of Mg2+ permeation through Mrs2.
Structure of human ZAC channel
ZAC is a Zn2+ and H⁺-activated cation channel and a critical target for neuropsychiatric drugs. we report the structures of human ZAC, providing insights into the gating and activation mechanisms of ZAC.
Network topology controls the fate of cells during development and disease
This study explores how cells decide their future states through genetic networks. By analyzing their structure, we uncovered principles that govern cell diversity and decision-making. These insights enhance our understanding of development, disease, and potential therapeutic strategies.
Exploiting Temporal Correlation of Fortunate Single Molecules for Background-free Super-resolution Imaging
Fortunate molecules (molecules with long blinking cycles) hold the key to quantitative super-resolution imaging (high SBR and a PAR-shift towards a single molecule limit), a step towards economical, reliable, and universal SMLM.
