Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Biomedical Research
The effects of obesity
One of the unanswered questions about obesity is how it correlates with a myriad of diseases such as heart failure, coronary artery disease, type 2 diabetes, non-alcoholic fatty liver disease, osteoarthritis, and various cancers.
MSK-CHORD: an AI-enabled, 24,950-patient clinicogenomic dataset for cancer research
AI annotation, tumor genomic profiling, and combination of other siloed datasets enables creation of a clinicogenomic, harmonized oncologic real-world dataset (MSK-CHORD). MSK-CHORD allows for study of cancer genotype-phenotype relationships at a scale previously impossible.
Epigenetic modulation via the C-terminal tail of H2A.Z
The histone tail, as part of the endogenous H2A.Z, or added in excess to nuclei/cells, exerts a large effect on nucleosome stability as well as on nuclear architecture, and its alternative molecular engagements explain the intranuclear heterogeneity of the H2A.Z-nucleosomes in vivo.
