AF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis
AF1Q is an oncogene with roles in leukemia and solid tumor progression. Despite its expression in neural tissues, no role for AF1Q in tumors of neural origin has been reported. We found AF1Q is a universal marker of neuroblastoma that is essential for neuroblastoma cell survival and tumorigenicity.
PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes
We identified PIEZO1 as a mechanical sensor to regulate the mechanical signaling that is critical for the cytotoxic T cells (CTLs) against tumor cells, creating potential venues to enhance the efficacy of targeted T cell immune therapies.
Redefining high risk multiple myeloma with an APOBEC/Inflammation-based classifier.
Multiple myeloma (MM), a malignancy of plasma cells in the bone marrow, remains a significant clinical challenge due to its diverse presentation and progression.
Unraveling the Sugary Code: N-Glycosylation's Impact on Protein Conformation and its Link to Disease
In the intricate dance of cellular processes, a seemingly modest tweak known as N-glycosylation takes center stage. This post-translational modification endows proteins with a sophisticated sugar code, dictating their conformation, assembly, and, crucially, their roles in various diseases.
Behind the scenes
Farcast's TruTumor histoculture platform captures dynamic interactions between tumor and immune components to predict response to anti-PD1 in head and neck cancer
