Teaching Cancer Prevention Where It Matters: Inside the CARES4You Study
What if cancer prevention started in a middle school science classroom, not a clinic?
Adolescents and young adults are the only U.S. group with rising cancer incidence, yet prevention often comes late—after behaviors like tobacco use, diet, and environmental exposures are ingrained.
Reprogramming the morphology of colorectal cancer cells in 3D cultures to enhance therapeutic response
By pairing 3D culture with high-throughput screening, our Communications Biology study reveals how architecture shapes signaling and drug sensitivity – offering insights that could transform treatment strategies for colorectal cancer.
Measurement of women's breast cancer risk
Breast cancer screening adjusted to each woman's risk seems attractive for many reasons, but an important prerequisite is - of course - that the risk measurement is valid. That is what we set out to test in the recent publication in British Journal of Cancer.
cfDNA dynamics decipher mechanism of action of Ibrutinib in patients with MCL
We investigated cfDNA dynamics prior to and during induction treatment of patients with MCL treated within the TRIANGLE trial and showed an early and superior disease clearance when treated with Ibrutinib and hints toward improved disease clearance in lymph nodes than using chemotherapy
The architectonics of cancer tissue: a “bulk” analytical framework to study cancer tissue organization
Solid tumors are diagnosed by histopathology, which recognizes abnormal tissue architecture. We asked whether these changes are random or follow recurring rules. Using large-scale bulk RNA-seq, we derived quantitative “architecture” signatures that stratify cancers and link to prognosis.
Real-time disease monitoring predicts early relapse and refines conventional imaging in patients with DLBCL
Monitoring lymphoma treatment has long relied on PET-CT scans, but these are imperfect. Circulating tumor DNA (ctDNA) offers a minimally invasive, highly specific way to track disease in real time. In our study, we explored how ctDNA can reshape response assessment in DLBCL.
DARPP‑32 Beyond the Brain: A Potential Regulator of Macrophage M2 Polarization Through STAT6 Signalling
DARPP-32 orchestrates macrophage polarization towards M2 subtype via JAK1/STAT6/SHP-1 axis, fostering an immunosuppressive tumor microenvironment supporting tumor growth.