How I discovered your fingertips could detect cancer!
This invited blog is based on the publication of our paper Russo, C., et al. Non-invasive screening of breast cancer from fingertip smears—a proof of concept study. Sci Rep 13, 1868 (2023). https://doi.org/10.1038/s41598-023-29036-7 in which was the 4th most downloaded cancer paper in 2023
DLGAP5 enhances bladder cancer chemoresistance by regulating glycolysis through MYC stabilization
Our study shows that DLGAP5 enhances gemcitabine resistance in bladder cancer by stabilizing MYC protein via USP11-mediated deubiquitination. This interaction boosts MYC-driven glycolysis, suggesting that targeting the DLGAP5-USP11-MYC axis could overcome resistance.
Translational and Clinical Comparison of Whole Genome and Transcriptome to Panel Sequencing in Precision Oncology
Cancer treatment has entered a new era where molecular insights are crucial for treatment decisions. Our study examined whether the sequencing method significantly affects therapy recommendations and implementations for patients with rare or advanced tumors.
MicroRNA dynamics, PTEN/PI3K/AKT signaling, and their relationship to breast cancer: prospects for pharmaceuticals and natural product application
Breast Cancer, PI3K/PTEN/AKT signaling pathway, microRNAs, Natural Products, Potential drugs.
Network topology controls the fate of cells during development and disease
This study explores how cells decide their future states through genetic networks. By analyzing their structure, we uncovered principles that govern cell diversity and decision-making. These insights enhance our understanding of development, disease, and potential therapeutic strategies.
Linking tissue injury to neural precursor reprogramming in gliomagenesis
In this article, we provide a behind-the-scenes narrative of a new publication from my lab, led by Akram Hamed, published today in Nature: Gliomagenesis mimics an injury response orchestrated by neural crest-like cells. https://www.nature.com/articles/s41586-024-08356-2
