Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: General & Internal Medicine
Behind the Paper: Survey of lived experiences and challenges in hepatitis B management and treatment
Over 250 million individuals are living with hepatitis B worldwide, most remain unaware of their infection. Major barriers to accessing diagnostics, routine management and treatment exist. Values and preferences of people with lived experience are essential to understand barriers.
Parkinson's Disease: Can Metabolomics Predict and Explain Its Onset?
The uncertain pathogenesis of Parkinson's disease (PD) is suspected to predate symptom onset. Our study delves into the metabolic associations of PD before and after its onset to provide additional insights into its multifaceted aetiology.
NCATS Tissue Chips in Space-The UW Kidney Chip Experiences
In this “Behind the Papers” post we describe the challenges faced to modify the kidney MPS perfusion system from a terrestrial lab to the ISS-NL for our two successful launches in 2019 (CRS-17) and 2022 (CRS-22) as well as the experimental results from CRS-17.
They shoot eyes in... Switzerland?
How a part-time mum came to write a paper on eye injuries by rubber scattershot after decades of private practice
How large language models can help scale citizen science in chronic disease research
We have observed a consistent desire among persons with chronic diseases to tell their story and be heard. Engaging them more in health research may demand new ways for capturing and analyzing such free-text narratives. Large language models can streamline the analysis and lead to novel insights.
Sex Differences in Fitted Face Mask Performance
“Have you ever noticed your mask leaking air around your nose or fogging up your glasses?”
To briefly describe a central study motivation, we asked participants this simple question before they undertook mask fit testing at the EPA Human Studies Facility located in Chapel Hill, North Carolina, USA.
Beyond calories: assessing post-prandial oxidative stress using a micro-NMR system
Traditional views of adverse health effects of macronutrient have largely centered around calories and the intake-expenditure balance. Recent advancements in the biomedical technology have allowed measurements of metabolic and physiologic responses to macronutrient.
Tepotinib in Asian patients with METex14 skipping NSCLC
VISION, the largest study of a MET inhibitor for rare NSCLC with METex14 skipping mutations, shows tepotinib's efficacy and safety in Asian patients align with overall results. It provides the first health-related quality of life assessment for this group, supporting once-daily tepotinib treatment.
The need for predictive biomarkers of tumor hypoxia
In our paper we showcased how to retain low-abundant signals of tumor hypoxia from spatial omics data for biomarker discovery. In this post, we want to emphasize why tumor hypoxia is relevant and why there is still an urgent need for predictive molecular biomarkers.
