Targeting fatty acid synthase in preclinical models of triple-negative breast cancer brain metastases synergizes with chemotherapy and impairs invasion
Metastatic triple-negative breast cancer cells need to acquire the ability to produce new fatty acids to more effectively colonize the brain. Our study investigates how this metabolic vulnerability can be targeted to increase efficacy of chemotherapies and impair cancer cell invasion.
Unveiling Single-Cell Resolution Insights into Epichaperomes in Tissues: Introducing the PU-TCO Clickable Epichaperome Probe
Discovering the secrets of neurodegenerative diseases and cancer at single-cell level precision - the PU-TCO clickable probe illuminates epichaperomes, offering insights into disease mechanisms at a cellular level.
Spatial Proteomics Offer Novel Insights into Rare Lymphomas with Sparse Tumor B-Cells
In Younes S et al. Blood Cancer J. 2024 [https://doi.org/10.1038/s41408-024-01073-z], we explore the cellular composition and spatial organization of two rare and related lymphomas, NLPHL and THRLBCL, to gain insight into their biological behavior.
Deep learning-based microsatellite instability predictor from prostate cancer whole-slide images
Researchers developed a deep learning predictor of MSI in prostate cancer using a large, real-world cohort of H&E whole slide images. The screening algorithm may be used to rapidly prioritize patients for confirmatory testing, which can identify MSI-high patients who may qualify for immunotherapy.
