Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
TISSUE: Predicting missing spatial gene expression with confidence
Several computational methods have been developed to augment spatially resolved single-cell transcriptomics to measure more genes. We developed TISSUE to build on these methods by providing confidence in these computational measurements and additional tools for performing data analysis.
Decoding Radiation-Induced Fibrosis: a computational approach to understanding the damage pathway
Computational modeling of radiation-induced lung fibrosis via the agent-based paradigm provides valuable insights into the initiation and progression of toxicity.
A Detour for Prostate Cancer Cell Survival and Growth
Second generation AR antagonists, abiraterone and enzalutamide, induce aberrant HGF/MET and Wnt pathways leading to increased XPO1 expression and ribosomal biosynthesis in double-null prostate cancer (DNPC). However, treatment with XPO1 and ribosomal inhibitors showed an improved antitumor response.
Are we prepared for the next pandemic? New tools for measurement and assessment
Studies show that standard preparedness measures do not predict COVID-19 outcomes, suggesting new measures are needed. But evaluating metrics is more than prediction. Measurement science points the way to tools that capture operational capabilities , including coordination and decisionmaking.
