Selection of Treatment Options for Locally Advanced Rectal Cancer: An MRI-based Risk Stratification Scoring System
We developed the mrDEC scoring system to accurately predict the prognosis of patients with LARC and to distinguish true high-risk patients from low-risk patients.
Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification
This study presents an optimized proteogenomic workflow for the discovery of neoantigens (in particular RNA-derived neoantigens) in a pan-cancer cohort and sheds light on the entity-agnostic prevalence of HLA-I peptide presentation of RNA processing events for tumor targeting.
Behind the Paper: “Molecular Disparities in Colorectal Cancers of White Americans, Alabama African Americans, and Oklahoma American Indians”
Hiroshi Y. Yamada, Upender Manne, Chinthalapally V. Rao
Auxiliary Diagnosis of Papillary Thyroid Carcinoma Based on Spectral Phenotype
This poster is about the paper "Auxiliary Diagnosis of Papillary Thyroid Carcinoma Based on Spectral Phenotype" published at Phenomics.
Stem cell-like CD8 T cells are at the heart of the anti-tumor response induced by PD-L1/TGFβ dual blockade in immune excluded tumors
In depth analysis of the CD8 T cells infiltrating an immune excluded tumor model revealed the presence of stem cell-like CD8 T cells that expanded in situ upon anti-PD-L1/TGFβ combination therapy fueling an efficient and IFNγ dependent anti-tumor response.
Integrating Somatic CNV and Gene Expression in Breast Cancers from Women with PTEN Hamartoma Tumor Syndrome
Copy number variation and transcript features from breast cancers arising in the setting of germline PTEN mutations revealed distinct biological characteristics compared to sporadic breast cancers.
Niche heterogeneity influences the outcomes in myeloproliferative neoplasms
The reasons underlying the different pathogenesis and response to therapies in the myeloproliferative neoplasms have remained enigmatic. Grockowiak et al. provide some clues emerging from disease-specific alterations in the interaction of hematopoietic stem cells with their bone marrow niches (1).
Unveiling the Intricate Dance of HSP90: A Master Conductor of Cellular Responses in Health and Disease
In the intricate world of cellular responses, a molecular maestro plays a pivotal role – HSP90. What makes HSP90 truly fascinating is its conformational flexibility. Scientists are now uncovering the profound impact of HSP90's conformational changes on cellular responses in health and disease.
Secondary versus de novo ontogeny for AML in the era of molecular genetics
AML has long been classified and prognosticated based on ontogeny, that is, whether it is de novo or secondary. But several reports have suggested that disease genetics drive these outcomes as opposed to ontogeny. Here, we examine this relationship in greater detail.
