Visible light accelerates skin wound healing and alleviates scar formation in mice by adjusting STAT3 signaling
In mice keratinocytes, upregulation of PI3Kβ by red light promotes the p-STAT3 and accelerates skin wound healing by; ROS induced by blue light inhibits the p-STAT3 and alleviates scar formation.
Unique Antibiotic Family
New antibiotics are a massive unmet need. The rise in antibiotic resistant bacteria is ever increasing such that antimicrobial resistance contributed to 5 million death last year, the next pandemic could be bacterial, and there are some conditions for which current antibiotics are ineffective.
Unravelling the bioactive potential of a bacterial symbiont of a tropical bird
Novel Amycolatopsis sp. PS_44_ISF1 isolated from the uropygial gland of Pachycephala schlegelii possesses the ability to produce a series of bioactive compounds, including two novel families of metabolites. Our study exemplifies the underexplored chemical potential of bacterial symbionts of birds.
Electrochemical CO2 Reduction to Methane by Triazole Molecules
Electrochemical conversion of CO2 into fuels and chemicals with high selectivity and activity is crucial. Our recent work highlights a promising method for CO2-to-CH4 with considerable selectivity and industrially relevant activity by triazole molecules in the presence of trace metal impurities.
Preliminary Phase 2a Readout for a Novel Drug Discovered and Designed Using Generative AI Sets a Major Milestone in AI-Powered Drug Discovery
Insilico Medicine’s AI-Designed Small Molecule Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis Yields Positive, Promising Phase 2 Trial Data
Enabling transport and metabolism in synthetic cells
Decarboxylation of L-malate coupled to L-malate/L-lactate exchange provides metabolic energy for the uptake and metabolism of nutrients in cell-like lipid vesicles.
Antibodies need teamwork!
We develop a novel approach to identify anti-bacterial antibodies from human B cells and reveal that some antibodies can act synergistically