Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Cell & Molecular Biology
Unveiling Single-Cell Resolution Insights into Epichaperomes in Tissues: Introducing the PU-TCO Clickable Epichaperome Probe
Discovering the secrets of neurodegenerative diseases and cancer at single-cell level precision - the PU-TCO clickable probe illuminates epichaperomes, offering insights into disease mechanisms at a cellular level.
A new automated, multiplex approach to studying shear stress mechanotransduction of circulating cells
As the mechanobiology of immune and cancer cells is gaining interest, we developed an easy to adopt, off-the-shelf system for subjecting many different samples to repeated cycles of fluid shear stress.
Behind the paper: Unraveling the molecular mechanism behind COVID-19 pulmonary pathologies associated with ferroptosis
How we found that ferroptosis is a key driver of lung damage in severe COVID-19 patients,
By Baiyu Qiu, Fereshteh Zandkarimi, Anjali Saqi and Brent R. Stockwell
Particle contaminants as potential disruptors of biomolecular condensates
Polystyrene nanoplastics trigger amyotrophic lateral sclerosis (ALS)-associated TAR DNA binding protein-43 (TDP-43) to undergo aberrant phase separation and exacerbate pathogenic tendency via persistent intracellular stimulation and direct interaction.
Essential Fatty Acids: A Potential Solution for Post-COVID-19 Long-Haul Manifestations
This blog was written by Undurti N. Das. Prof. Das is a clinical immunologist, endocrinologist and the founder president and chief executive officer of UND Life Sciences.
Precisely programming gene expression in plants
We have developed CRISPRi-based circuits for programming gene expression in plants. These circuits are modular, compact, orthogonal, reversible and programmable and function in various plant species.
Unlocking the evolutionary mechanism of Intermolecular Diels-Alderases from Mulberry Trees
In organic synthesis, the Diels-Alder reaction is pivotal. Seeking eco-friendly alternatives, researchers explore natural Diels-Alderases, enzymes that catalyze this reaction. Xiaoguang Lei's lab uncovers evolutionary mechanisms in plant-derived Diels-Alderases, especially from mulberry trees.
Homotrimeric architecture of viral G protein-coupled receptor UL78
UL78, a human cytomegalovirus encoded GPCR, interrupts normal signaling or presents oligomers to modulate functions of other viral GPCRs and host GPCRs. In this study, we report the cryo-EM structure of UL78 and unveil a novel form of GPCR oligomerization unseen before − a homotrimeric architecture.
