Behind the Paper
The real stories behind the latest research papers, from conception to publication, the highs and the lows
Filtered by: Biomedical Research
The Explosive Passion of Youth Behind Ancient Stories
XPR1, the sole protein that export phosphate out of cells in human. We found that XPR1 forms a membrane-spanning channel and employs a relay” process to facilitate phosphate passage through the channel, maintaining the cellular phosphate levels within a reasonable range.
T cells in amyotrophic lateral sclerosis
The immune system’s role in amyotrophic lateral sclerosis (ALS) progression is increasingly recognized, but the impact of peripheral immune cells remains unclear. Using single-cell RNA sequencing, we analyzed blood immune cells to explore their link to disease progression in ALS patients.
Genome organization around inter-chromosomal transcription hubs
The genome architecture is a critical element in transcriptional regulation. Our study reveals an intricate network of interactions between related genomic loci, even in the absence of direct regulatory mechanisms, and provides new perspectives on the evolutionary significance of these interactions.
Behind the paper: ADNP is essential for sex-dependent hippocampal neurogenesis, through male unfolded protein response and female mitochondrial gene regulation
Surprisingly, dramatically different molecular pathways regulate adult neurogenesis in males and females. Importantly, these pathways are strongly impacted by the major autism/intellectual disability gene, ADNP and corrected by the ADNP neuroprotective site, the investigational drug davunetide.
The LEANORA study: Understanding the pharmacokinetics and pharmacogenomics of ribociclib in Black women
This study examined ribociclib pharmacokinetics and pharmacogenomics in 14 Black women with advanced breast cancer. The LEANORA study (NCT04657679) revealed that the ribociclib exposure and toxicity profile were similar between intermediate/normal and poor CYP3A5 metabolizers.
Dynamics of the Blood Plasma Proteome During Hyperacute HIV-1 Infection
In our recent study in Nature Communications, we employed cutting-edge proteomics to explore changes in blood plasma proteins during early HIV-1 infection. The results advance our understanding of early host responses and highlight mechanisms that influence viral control and disease progression.
How bad cholesterol is removed from blood
Cardiovascular disease is the number one cause of human mortality. New structural information helps to develop future therapeutic interventions for this chronic, human health problem.
Bridging the Gap: Enhancing Diversity in Clinical Trials to Advance Medicine
Breakthroughs to advance human health require clinical trials that include communities less engaged in research and development of potentially lifesaving medical interventions. To address this, a coalition created the Equitable Breakthroughs in Medicine Development Site Maturity Assessment Model.